Immune-mediated: Certain drugs can trigger an immune response that leads to the production of antibodies targeting and destroying platelets. This immune-mediated destruction is a common mechanism of drug-induced thrombocytopenia (DITP). Examples of drugs associated with immune-mediated DITP include specific antibiotics (e.g., penicillins and sulfonamides), nonsteroidal anti-inflammatory drugs (NSAIDs), and some anticonvulsants.
Non-immune-mediated: Other drugs can cause thrombocytopenia through non-immune mechanisms, such as direct toxicity to the bone marrow, where platelets are produced. For instance, chemotherapeutic agents can suppress bone marrow function, resulting in decreased platelet production.
