December 19, 2025
Ulcerative Colitis
The diagnosis of UC is best made with endoscopy and mucosal biopsy for
histopathology. Laboratory studies are helpful to exclude other diagnoses and assess the patient's nutritional status, but serologic markers can assist in the diagnosis of inflammatory bowel disease. Radiographic imaging has an important role in the workup of patients with suspected inflammatory bowel disease and in the
differentiation of UC from Crohn disease by demonstrating fistulae or the presence of small bowel disease seen only in Crohn disease.
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