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September 10, 2024

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Thyroid storm

 

Thyroid Storm

Thyroid storm is a rare and life-threatening condition characterized by an acute exacerbation of thyrotoxicosis, marked by elevated levels of free triiodothyronine (T3) or free thyroxine (T4) and suppressed thyrotropin (TSH). It presents with severe clinical symptoms and can lead to multiorgan failure, affecting various organ systems, including the central nervous system, cardiovascular system, hepatic system, pulmonary system, respiratory system, digestive system, and gastrointestinal excretory system.
Specific Strategic Steps for Treatment
  • Therapy to control increased adrenergic tone: Beta-blocker
  • Therapy to reduce thyroid hormone synthesis: Thionamide
  • Therapy to reduce the release of thyroid hormone: Iodine solution
  • Therapy to block peripheral conversion of T4 to T3: Iodinated radiocontrast agent, glucocorticoid, PTU, propranolol
  • Therapy to reduce enterohepatic recycling of thyroid hormone: Bile acid sequestrant

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